Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain
Identifieur interne : 000599 ( Main/Exploration ); précédent : 000598; suivant : 000600Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain
Auteurs : Lei He ; Wanbo Tai ; Jiangfan Li ; Yuehong Chen ; Yaning Gao ; Junfeng Li ; Shihui Sun ; Yusen Zhou [République populaire de Chine] ; Lanying Du ; Guangyu ZhaoSource :
- Viruses [ 1999-4915 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps neutralisants (immunologie), Anticorps à domaine unique (immunologie), Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Domaines protéiques (immunologie), Humains, Liaison aux protéines, Pepsine A (), Récepteurs viraux (immunologie), Température élevée, Tests de neutralisation, Urée ().
- MESH :
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Camelus, Hot Temperature, Humans, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests, Pepsin A (chemistry), Protein Binding, Protein Domains (immunology), Receptors, Virus (immunology), Single-Domain Antibodies (immunology), Urea (chemistry).
- MESH :
- chemical , chemistry : Pepsin A, Urea.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Receptors, Virus, Single-Domain Antibodies.
- immunology : Protein Domains.
- Animals, Camelus, Hot Temperature, Humans, Middle East Respiratory Syndrome Coronavirus, Neutralization Tests, Protein Binding.
Abstract
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), an infectious coronavirus first reported in 2012, has a mortality rate greater than 35%. Therapeutic antibodies are key tools for preventing and treating MERS-CoV infection, but to date no such agents have been approved for treatment of this virus. Nanobodies (Nbs) are camelid heavy chain variable domains with properties distinct from those of conventional antibodies and antibody fragments. We generated two oligomeric Nbs by linking two or three monomeric Nbs (Mono-Nbs) targeting the MERS-CoV receptor-binding domain (RBD), and compared their RBD-binding affinity, RBD–receptor binding inhibition, stability, and neutralizing and cross-neutralizing activity against MERS-CoV. Relative to Mono-Nb, dimeric Nb (Di-Nb) and trimeric Nb (Tri-Nb) had significantly greater ability to bind MERS-CoV RBD proteins with or without mutations in the RBD, thereby potently blocking RBD–MERS-CoV receptor binding. The engineered oligomeric Nbs were very stable under extreme conditions, including low or high pH, protease (pepsin), chaotropic denaturant (urea), and high temperature. Importantly, Di-Nb and Tri-Nb exerted significantly elevated broad-spectrum neutralizing activity against at least 19 human and camel MERS-CoV strains isolated in different countries and years. Overall, the engineered Nbs could be developed into effective therapeutic agents for prevention and treatment of MERS-CoV infection.
Url:
DOI: 10.3390/v11020166
PubMed: 30791410
PubMed Central: 6410414
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001218
- to stream Pmc, to step Curation: 001218
- to stream Pmc, to step Checkpoint: 000327
- to stream PubMed, to step Corpus: 000637
- to stream PubMed, to step Curation: 000637
- to stream PubMed, to step Checkpoint: 000584
- to stream Ncbi, to step Merge: 002118
- to stream Ncbi, to step Curation: 002118
- to stream Ncbi, to step Checkpoint: 002118
- to stream Main, to step Merge: 000602
- to stream Main, to step Curation: 000599
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain</title><author><name sortKey="He, Lei" sort="He, Lei" uniqKey="He L" first="Lei" last="He">Lei He</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name><affiliation><nlm:aff id="af2-viruses-11-00166">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA;<email>wtai@nybc.org</email> (W.T.);<email>ygao@nybc.org</email> (Y.G.)</nlm:aff></affiliation></author><author><name sortKey="Li, Jiangfan" sort="Li, Jiangfan" uniqKey="Li J" first="Jiangfan" last="Li">Jiangfan Li</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Chen, Yuehong" sort="Chen, Yuehong" uniqKey="Chen Y" first="Yuehong" last="Chen">Yuehong Chen</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Gao, Yaning" sort="Gao, Yaning" uniqKey="Gao Y" first="Yaning" last="Gao">Yaning Gao</name><affiliation><nlm:aff id="af2-viruses-11-00166">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA;<email>wtai@nybc.org</email> (W.T.);<email>ygao@nybc.org</email> (Y.G.)</nlm:aff></affiliation></author><author><name sortKey="Li, Junfeng" sort="Li, Junfeng" uniqKey="Li J" first="Junfeng" last="Li">Junfeng Li</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00166">Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052</wicri:regionArea><wicri:noRegion>Zhengzhou 450052</wicri:noRegion></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation><nlm:aff id="af2-viruses-11-00166">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA;<email>wtai@nybc.org</email> (W.T.);<email>ygao@nybc.org</email> (Y.G.)</nlm:aff></affiliation></author><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30791410</idno><idno type="pmc">6410414</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410414</idno><idno type="RBID">PMC:6410414</idno><idno type="doi">10.3390/v11020166</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">001218</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001218</idno><idno type="wicri:Area/Pmc/Curation">001218</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001218</idno><idno type="wicri:Area/Pmc/Checkpoint">000327</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000327</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:30791410</idno><idno type="wicri:Area/PubMed/Corpus">000637</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000637</idno><idno type="wicri:Area/PubMed/Curation">000637</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000637</idno><idno type="wicri:Area/PubMed/Checkpoint">000584</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000584</idno><idno type="wicri:Area/Ncbi/Merge">002118</idno><idno type="wicri:Area/Ncbi/Curation">002118</idno><idno type="wicri:Area/Ncbi/Checkpoint">002118</idno><idno type="wicri:Area/Main/Merge">000602</idno><idno type="wicri:Area/Main/Curation">000599</idno><idno type="wicri:Area/Main/Exploration">000599</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain</title><author><name sortKey="He, Lei" sort="He, Lei" uniqKey="He L" first="Lei" last="He">Lei He</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name><affiliation><nlm:aff id="af2-viruses-11-00166">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA;<email>wtai@nybc.org</email> (W.T.);<email>ygao@nybc.org</email> (Y.G.)</nlm:aff></affiliation></author><author><name sortKey="Li, Jiangfan" sort="Li, Jiangfan" uniqKey="Li J" first="Jiangfan" last="Li">Jiangfan Li</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Chen, Yuehong" sort="Chen, Yuehong" uniqKey="Chen Y" first="Yuehong" last="Chen">Yuehong Chen</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Gao, Yaning" sort="Gao, Yaning" uniqKey="Gao Y" first="Yaning" last="Gao">Yaning Gao</name><affiliation><nlm:aff id="af2-viruses-11-00166">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA;<email>wtai@nybc.org</email> (W.T.);<email>ygao@nybc.org</email> (Y.G.)</nlm:aff></affiliation></author><author><name sortKey="Li, Junfeng" sort="Li, Junfeng" uniqKey="Li J" first="Junfeng" last="Li">Junfeng Li</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00166">Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052</wicri:regionArea><wicri:noRegion>Zhengzhou 450052</wicri:noRegion></affiliation></author><author><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><affiliation><nlm:aff id="af2-viruses-11-00166">Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA;<email>wtai@nybc.org</email> (W.T.);<email>ygao@nybc.org</email> (Y.G.)</nlm:aff></affiliation></author><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><affiliation><nlm:aff id="af1-viruses-11-00166">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China;<email>helei_happy@126.com</email> (L.H.);<email>anatee@163.com</email> (J.L.);<email>chenyuehong.happy@163.com</email> (Y.C.);<email>lijunfeng2113@126.com</email> (J.L.);<email>sunsh01@163.com</email> (S.S.)</nlm:aff></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (immunology)</term><term>Camelus</term><term>Hot Temperature</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Neutralization Tests</term><term>Pepsin A (chemistry)</term><term>Protein Binding</term><term>Protein Domains (immunology)</term><term>Receptors, Virus (immunology)</term><term>Single-Domain Antibodies (immunology)</term><term>Urea (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps neutralisants (immunologie)</term><term>Anticorps à domaine unique (immunologie)</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Domaines protéiques (immunologie)</term><term>Humains</term><term>Liaison aux protéines</term><term>Pepsine A ()</term><term>Récepteurs viraux (immunologie)</term><term>Température élevée</term><term>Tests de neutralisation</term><term>Urée ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Pepsin A</term><term>Urea</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Receptors, Virus</term><term>Single-Domain Antibodies</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Anticorps à domaine unique</term><term>Domaines protéiques</term><term>Récepteurs viraux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Protein Domains</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Hot Temperature</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Neutralization Tests</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Liaison aux protéines</term><term>Pepsine A</term><term>Température élevée</term><term>Tests de neutralisation</term><term>Urée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), an infectious coronavirus first reported in 2012, has a mortality rate greater than 35%. Therapeutic antibodies are key tools for preventing and treating MERS-CoV infection, but to date no such agents have been approved for treatment of this virus. Nanobodies (Nbs) are camelid heavy chain variable domains with properties distinct from those of conventional antibodies and antibody fragments. We generated two oligomeric Nbs by linking two or three monomeric Nbs (Mono-Nbs) targeting the MERS-CoV receptor-binding domain (RBD), and compared their RBD-binding affinity, RBD–receptor binding inhibition, stability, and neutralizing and cross-neutralizing activity against MERS-CoV. Relative to Mono-Nb, dimeric Nb (Di-Nb) and trimeric Nb (Tri-Nb) had significantly greater ability to bind MERS-CoV RBD proteins with or without mutations in the RBD, thereby potently blocking RBD–MERS-CoV receptor binding. The engineered oligomeric Nbs were very stable under extreme conditions, including low or high pH, protease (pepsin), chaotropic denaturant (urea), and high temperature. Importantly, Di-Nb and Tri-Nb exerted significantly elevated broad-spectrum neutralizing activity against at least 19 human and camel MERS-CoV strains isolated in different countries and years. Overall, the engineered Nbs could be developed into effective therapeutic agents for prevention and treatment of MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. Van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J. Tang</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name></author><author><name sortKey="Adney, D R" uniqKey="Adney D">D.R. Adney</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. Van Doremalen</name></author><author><name sortKey="Brown, V R" uniqKey="Brown V">V.R. Brown</name></author><author><name sortKey="Miazgowicz, K L" uniqKey="Miazgowicz K">K.L. Miazgowicz</name></author><author><name sortKey="Milne Price, S" uniqKey="Milne Price S">S. Milne-Price</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T. Bushmaker</name></author><author><name sortKey="Rosenke, R" uniqKey="Rosenke R">R. Rosenke</name></author><author><name sortKey="Scott, D" uniqKey="Scott D">D. Scott</name></author><author><name sortKey="Hawkinson, A" uniqKey="Hawkinson A">A. Hawkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anthony, S J" uniqKey="Anthony S">S.J. Anthony</name></author><author><name sortKey="Gilardi, K" uniqKey="Gilardi K">K. Gilardi</name></author><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author><author><name sortKey="Goldstein, T" uniqKey="Goldstein T">T. Goldstein</name></author><author><name sortKey="Ssebide, B" uniqKey="Ssebide B">B. Ssebide</name></author><author><name sortKey="Mbabazi, R" uniqKey="Mbabazi R">R. Mbabazi</name></author><author><name sortKey="Navarrete Macias, I" uniqKey="Navarrete Macias I">I. Navarrete-Macias</name></author><author><name sortKey="Liang, E" uniqKey="Liang E">E. Liang</name></author><author><name sortKey="Wells, H" uniqKey="Wells H">H. Wells</name></author><author><name sortKey="Hicks, A" uniqKey="Hicks A">A. Hicks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K P" uniqKey="Lau S">S.K.P. Lau</name></author><author><name sortKey="Wong, A C P" uniqKey="Wong A">A.C.P. Wong</name></author><author><name sortKey="Lau, T C K" uniqKey="Lau T">T.C.K. Lau</name></author><author><name sortKey="Woo, P C Y" uniqKey="Woo P">P.C.Y. Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name></author><author><name sortKey="Hijazeen, Z S" uniqKey="Hijazeen Z">Z.S. Hijazeen</name></author><author><name sortKey="Holloway, P" uniqKey="Holloway P">P. Holloway</name></author><author><name sortKey="Al, O B" uniqKey="Al O">O.B. Al</name></author><author><name sortKey="Mcdowell, C" uniqKey="Mcdowell C">C. McDowell</name></author><author><name sortKey="Adney, D" uniqKey="Adney D">D. Adney</name></author><author><name sortKey="Talafha, H A" uniqKey="Talafha H">H.A. Talafha</name></author><author><name sortKey="Guitian, J" uniqKey="Guitian J">J. Guitian</name></author><author><name sortKey="Steel, J" uniqKey="Steel J">J. Steel</name></author><author><name sortKey="Amarin, N" uniqKey="Amarin N">N. Amarin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madani, T A" uniqKey="Madani T">T.A. Madani</name></author><author><name sortKey="Azhar, E I" uniqKey="Azhar E">E.I. Azhar</name></author><author><name sortKey="Hashem, A M" uniqKey="Hashem A">A.M. Hashem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, M G" uniqKey="Hemida M">M.G. Hemida</name></author><author><name sortKey="Elmoslemany, A" uniqKey="Elmoslemany A">A. Elmoslemany</name></author><author><name sortKey="Al Hizab, F" uniqKey="Al Hizab F">F. Al-Hizab</name></author><author><name sortKey="Alnaeem, A" uniqKey="Alnaeem A">A. Alnaeem</name></author><author><name sortKey="Almathen, F" uniqKey="Almathen F">F. Almathen</name></author><author><name sortKey="Faye, B" uniqKey="Faye B">B. Faye</name></author><author><name sortKey="Chu, D K" uniqKey="Chu D">D.K. Chu</name></author><author><name sortKey="Perera, R A" uniqKey="Perera R">R.A. Perera</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunter, J C" uniqKey="Hunter J">J.C. Hunter</name></author><author><name sortKey="Nguyen, D" uniqKey="Nguyen D">D. Nguyen</name></author><author><name sortKey="Aden, B" uniqKey="Aden B">B. Aden</name></author><author><name sortKey="Al, B Z" uniqKey="Al B">B.Z. Al</name></author><author><name sortKey="Al, D W" uniqKey="Al D">D.W. Al</name></author><author><name sortKey="Abu, E K" uniqKey="Abu E">E.K. Abu</name></author><author><name sortKey="Khudair, A" uniqKey="Khudair A">A. Khudair</name></author><author><name sortKey="Al, M M" uniqKey="Al M">M.M. Al</name></author><author><name sortKey="El, S F" uniqKey="El S">S.F. El</name></author><author><name sortKey="Imambaccus, H" uniqKey="Imambaccus H">H. Imambaccus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alhakeem, R F" uniqKey="Alhakeem R">R.F. Alhakeem</name></author><author><name sortKey="Midgley, C M" uniqKey="Midgley C">C.M. Midgley</name></author><author><name sortKey="Assiri, A M" uniqKey="Assiri A">A.M. Assiri</name></author><author><name sortKey="Alessa, M" uniqKey="Alessa M">M. Alessa</name></author><author><name sortKey="Al, H H" uniqKey="Al H">H.H. Al</name></author><author><name sortKey="Saeed, A B" uniqKey="Saeed A">A.B. Saeed</name></author><author><name sortKey="Almasri, M M" uniqKey="Almasri M">M.M. Almasri</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Abedi, G R" uniqKey="Abedi G">G.R. Abedi</name></author><author><name sortKey="Abdalla, O" uniqKey="Abdalla O">O. Abdalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Chughtai, A A" uniqKey="Chughtai A">A.A. Chughtai</name></author><author><name sortKey="Dyda, A" uniqKey="Dyda A">A. Dyda</name></author><author><name sortKey="Macintyre, C R" uniqKey="Macintyre C">C.R. MacIntyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, J Y" uniqKey="Choi J">J.Y. Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S S" uniqKey="Lee S">S.S. Lee</name></author><author><name sortKey="Wong, N S" uniqKey="Wong N">N.S. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y. Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J. Bao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name></author><author><name sortKey="Dekkers, D H" uniqKey="Dekkers D">D.H. Dekkers</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Muller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Demmers, J A" uniqKey="Demmers J">J.A. Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A. Zaki</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y. Zhu</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L. Qin</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Rajashankar, K R" uniqKey="Rajashankar K">K.R. Rajashankar</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S.S. Agnihothram</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name></author><author><name sortKey="Lin, Y L" uniqKey="Lin Y">Y.L. Lin</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Zhang, N" uniqKey="Zhang N">N. Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, N" uniqKey="Zhang N">N. Zhang</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J. Tang</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q. Zhu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Tseng, C K" uniqKey="Tseng C">C.K. Tseng</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Fett, C A" uniqKey="Fett C">C.A. Fett</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, N" uniqKey="Zhang N">N. Zhang</name></author><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R. Channappanavar</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J. Tang</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T. Garron</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Tasneem, S" uniqKey="Tasneem S">S. Tasneem</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, H" uniqKey="Qiu H">H. Qiu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Xiao, H" uniqKey="Xiao H">H. Xiao</name></author><author><name sortKey="Feng, J" uniqKey="Feng J">J. Feng</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Qiu, H" uniqKey="Qiu H">H. Qiu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z. Kou</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H. Yu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D. Corti</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J. Zhao</name></author><author><name sortKey="Pedotti, M" uniqKey="Pedotti M">M. Pedotti</name></author><author><name sortKey="Simonelli, L" uniqKey="Simonelli L">L. Simonelli</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S. Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C. Fett</name></author><author><name sortKey="Fernandez Rodriguez, B" uniqKey="Fernandez Rodriguez B">B. Fernandez-Rodriguez</name></author><author><name sortKey="Foglierini, M" uniqKey="Foglierini M">M. Foglierini</name></author><author><name sortKey="Agatic, G" uniqKey="Agatic G">G. Agatic</name></author><author><name sortKey="Vanzetta, F" uniqKey="Vanzetta F">F. Vanzetta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T. Ying</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P. Prabakaran</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W. Shi</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Dimitrov, D S" uniqKey="Dimitrov D">D.S. Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Zuo, T" uniqKey="Zuo T">T. Zuo</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Poon, K M" uniqKey="Poon K">K.M. Poon</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J. Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lowe, D" uniqKey="Lowe D">D. Lowe</name></author><author><name sortKey="Dudgeon, K" uniqKey="Dudgeon K">K. Dudgeon</name></author><author><name sortKey="Rouet, R" uniqKey="Rouet R">R. Rouet</name></author><author><name sortKey="Schofield, P" uniqKey="Schofield P">P. Schofield</name></author><author><name sortKey="Jermutus, L" uniqKey="Jermutus L">L. Jermutus</name></author><author><name sortKey="Christ, D" uniqKey="Christ D">D. Christ</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rouet, R" uniqKey="Rouet R">R. Rouet</name></author><author><name sortKey="Lowe, D" uniqKey="Lowe D">D. Lowe</name></author><author><name sortKey="Christ, D" uniqKey="Christ D">D. Christ</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chames, P" uniqKey="Chames P">P. Chames</name></author><author><name sortKey="Van, R M" uniqKey="Van R">R.M. Van</name></author><author><name sortKey="Weiss, E" uniqKey="Weiss E">E. Weiss</name></author><author><name sortKey="Baty, D" uniqKey="Baty D">D. Baty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siontorou, C G" uniqKey="Siontorou C">C.G. Siontorou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wesolowski, J" uniqKey="Wesolowski J">J. Wesolowski</name></author><author><name sortKey="Alzogaray, V" uniqKey="Alzogaray V">V. Alzogaray</name></author><author><name sortKey="Reyelt, J" uniqKey="Reyelt J">J. Reyelt</name></author><author><name sortKey="Unger, M" uniqKey="Unger M">M. Unger</name></author><author><name sortKey="Juarez, K" uniqKey="Juarez K">K. Juarez</name></author><author><name sortKey="Urrutia, M" uniqKey="Urrutia M">M. Urrutia</name></author><author><name sortKey="Cauerhff, A" uniqKey="Cauerhff A">A. Cauerhff</name></author><author><name sortKey="Danquah, W" uniqKey="Danquah W">W. Danquah</name></author><author><name sortKey="Rissiek, B" uniqKey="Rissiek B">B. Rissiek</name></author><author><name sortKey="Scheuplein, F" uniqKey="Scheuplein F">F. Scheuplein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hmila, I" uniqKey="Hmila I">I. Hmila</name></author><author><name sortKey="Abdallah, R B" uniqKey="Abdallah R">R.B. Abdallah</name></author><author><name sortKey="Saerens, D" uniqKey="Saerens D">D. Saerens</name></author><author><name sortKey="Benlasfar, Z" uniqKey="Benlasfar Z">Z. Benlasfar</name></author><author><name sortKey="Conrath, K" uniqKey="Conrath K">K. Conrath</name></author><author><name sortKey="Ayeb, M E" uniqKey="Ayeb M">M.E. Ayeb</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author><author><name sortKey="Bouhaouala Zahar, B" uniqKey="Bouhaouala Zahar B">B. Bouhaouala-Zahar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Els, C K" uniqKey="Els C">C.K. Els</name></author><author><name sortKey="Lauwereys, M" uniqKey="Lauwereys M">M. Lauwereys</name></author><author><name sortKey="Wyns, L" uniqKey="Wyns L">L. Wyns</name></author><author><name sortKey="Muyldermans, S" uniqKey="Muyldermans S">S. Muyldermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laursen, N S" uniqKey="Laursen N">N.S. Laursen</name></author><author><name sortKey="Friesen, R H E" uniqKey="Friesen R">R.H.E. Friesen</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X. Zhu</name></author><author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M. Jongeneelen</name></author><author><name sortKey="Blokland, S" uniqKey="Blokland S">S. Blokland</name></author><author><name sortKey="Vermond, J" uniqKey="Vermond J">J. Vermond</name></author><author><name sortKey="Van Eijgen, A" uniqKey="Van Eijgen A">A. van Eijgen</name></author><author><name sortKey="Tang, C" uniqKey="Tang C">C. Tang</name></author><author><name sortKey="Van Diepen, H" uniqKey="Van Diepen H">H. van Diepen</name></author><author><name sortKey="Obmolova, G" uniqKey="Obmolova G">G. Obmolova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="He, L" uniqKey="He L">L. He</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Qiu, H" uniqKey="Qiu H">H. Qiu</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X. Tao</name></author><author><name sortKey="Tseng, C K" uniqKey="Tseng C">C.K. Tseng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="He, L" uniqKey="He L">L. He</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Luo, C" uniqKey="Luo C">C. Luo</name></author><author><name sortKey="Li, P" uniqKey="Li P">P. Li</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H. Zhao</name></author><author><name sortKey="Fremont, D H" uniqKey="Fremont D">D.H. Fremont</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Lu, H" uniqKey="Lu H">H. Lu</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P. Siddiqui</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Tai, W" uniqKey="Tai W">W. Tai</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. Sun</name></author><author><name sortKey="Tseng, C K" uniqKey="Tseng C">C.K. Tseng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Gao, J" uniqKey="Gao J">J. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, T C" uniqKey="Chou T">T.C. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biacchesi, S" uniqKey="Biacchesi S">S. Biacchesi</name></author><author><name sortKey="Skiadopoulos, M H" uniqKey="Skiadopoulos M">M.H. Skiadopoulos</name></author><author><name sortKey="Yang, L" uniqKey="Yang L">L. Yang</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Collins, P L" uniqKey="Collins P">P.L. Collins</name></author><author><name sortKey="Buchholz, U J" uniqKey="Buchholz U">U.J. Buchholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaiotto, T" uniqKey="Gaiotto T">T. Gaiotto</name></author><author><name sortKey="Hufton, S E" uniqKey="Hufton S">S.E. Hufton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ardekani, L S" uniqKey="Ardekani L">L.S. Ardekani</name></author><author><name sortKey="Gargari, S L" uniqKey="Gargari S">S.L. Gargari</name></author><author><name sortKey="Rasooli, I" uniqKey="Rasooli I">I. Rasooli</name></author><author><name sortKey="Bazl, M R" uniqKey="Bazl M">M.R. Bazl</name></author><author><name sortKey="Mohammadi, M" uniqKey="Mohammadi M">M. Mohammadi</name></author><author><name sortKey="Ebrahimizadeh, W" uniqKey="Ebrahimizadeh W">W. Ebrahimizadeh</name></author><author><name sortKey="Bakherad, H" uniqKey="Bakherad H">H. Bakherad</name></author><author><name sortKey="Zare, H" uniqKey="Zare H">H. Zare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussack, G" uniqKey="Hussack G">G. Hussack</name></author><author><name sortKey="Hirama, T" uniqKey="Hirama T">T. Hirama</name></author><author><name sortKey="Ding, W" uniqKey="Ding W">W. Ding</name></author><author><name sortKey="Mackenzie, R" uniqKey="Mackenzie R">R. Mackenzie</name></author><author><name sortKey="Tanha, J" uniqKey="Tanha J">J. Tanha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aldeghaither, D" uniqKey="Aldeghaither D">D. AlDeghaither</name></author><author><name sortKey="Smaglo, B G" uniqKey="Smaglo B">B.G. Smaglo</name></author><author><name sortKey="Weiner, L M" uniqKey="Weiner L">L.M. Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ibanez, L I" uniqKey="Ibanez L">L.I. Ibanez</name></author><author><name sortKey="De, F M" uniqKey="De F">F.M. De</name></author><author><name sortKey="Hultberg, A" uniqKey="Hultberg A">A. Hultberg</name></author><author><name sortKey="Verrips, T" uniqKey="Verrips T">T. Verrips</name></author><author><name sortKey="Temperton, N" uniqKey="Temperton N">N. Temperton</name></author><author><name sortKey="Weiss, R A" uniqKey="Weiss R">R.A. Weiss</name></author><author><name sortKey="Vandevelde, W" uniqKey="Vandevelde W">W. Vandevelde</name></author><author><name sortKey="Schepens, B" uniqKey="Schepens B">B. Schepens</name></author><author><name sortKey="Vanlandschoot, P" uniqKey="Vanlandschoot P">P. Vanlandschoot</name></author><author><name sortKey="Saelens, X" uniqKey="Saelens X">X. Saelens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, T" uniqKey="Li T">T. Li</name></author><author><name sortKey="Bourgeois, J P" uniqKey="Bourgeois J">J.P. Bourgeois</name></author><author><name sortKey="Celli, S" uniqKey="Celli S">S. Celli</name></author><author><name sortKey="Glacial, F" uniqKey="Glacial F">F. Glacial</name></author><author><name sortKey="Le Sourd, A M" uniqKey="Le Sourd A">A.M. Le Sourd</name></author><author><name sortKey="Mecheri, S" uniqKey="Mecheri S">S. Mecheri</name></author><author><name sortKey="Weksler, B" uniqKey="Weksler B">B. Weksler</name></author><author><name sortKey="Romero, I" uniqKey="Romero I">I. Romero</name></author><author><name sortKey="Couraud, P O" uniqKey="Couraud P">P.O. Couraud</name></author><author><name sortKey="Rougeon, F" uniqKey="Rougeon F">F. Rougeon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, A" uniqKey="Liu A">A. Liu</name></author><author><name sortKey="Yin, K" uniqKey="Yin K">K. Yin</name></author><author><name sortKey="Mi, L" uniqKey="Mi L">L. Mi</name></author><author><name sortKey="Ma, M" uniqKey="Ma M">M. Ma</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Wei, W" uniqKey="Wei W">W. Wei</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bannas, P" uniqKey="Bannas P">P. Bannas</name></author><author><name sortKey="Hambach, J" uniqKey="Hambach J">J. Hambach</name></author><author><name sortKey="Koch Nolte, F" uniqKey="Koch Nolte F">F. Koch-Nolte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X. Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P. Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D. Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L. Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Roy, M" uniqKey="Van Roy M">M. Van Roy</name></author><author><name sortKey="Ververken, C" uniqKey="Ververken C">C. Ververken</name></author><author><name sortKey="Beirnaert, E" uniqKey="Beirnaert E">E. Beirnaert</name></author><author><name sortKey="Hoefman, S" uniqKey="Hoefman S">S. Hoefman</name></author><author><name sortKey="Kolkman, J" uniqKey="Kolkman J">J. Kolkman</name></author><author><name sortKey="Vierboom, M" uniqKey="Vierboom M">M. Vierboom</name></author><author><name sortKey="Breedveld, E" uniqKey="Breedveld E">E. Breedveld</name></author><author><name sortKey="Hart, B" uniqKey="Hart B">B. Hart</name></author><author><name sortKey="Poelmans, S" uniqKey="Poelmans S">S. Poelmans</name></author><author><name sortKey="Bontinck, L" uniqKey="Bontinck L">L. Bontinck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Okba, N M" uniqKey="Okba N">N.M. Okba</name></author><author><name sortKey="Gutierrez Alvarez, J" uniqKey="Gutierrez Alvarez J">J. Gutierrez-Alvarez</name></author><author><name sortKey="Drabek, D" uniqKey="Drabek D">D. Drabek</name></author><author><name sortKey="Van Dieren, B" uniqKey="Van Dieren B">B. van Dieren</name></author><author><name sortKey="Widagdo, W" uniqKey="Widagdo W">W. Widagdo</name></author><author><name sortKey="Lamers, M M" uniqKey="Lamers M">M.M. Lamers</name></author><author><name sortKey="Widjaja, I" uniqKey="Widjaja I">I. Widjaja</name></author><author><name sortKey="Fernandez Delgado, R" uniqKey="Fernandez Delgado R">R. Fernandez-Delgado</name></author><author><name sortKey="Sola, I" uniqKey="Sola I">I. Sola</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Yuehong" sort="Chen, Yuehong" uniqKey="Chen Y" first="Yuehong" last="Chen">Yuehong Chen</name><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name><name sortKey="Gao, Yaning" sort="Gao, Yaning" uniqKey="Gao Y" first="Yaning" last="Gao">Yaning Gao</name><name sortKey="He, Lei" sort="He, Lei" uniqKey="He L" first="Lei" last="He">Lei He</name><name sortKey="Li, Jiangfan" sort="Li, Jiangfan" uniqKey="Li J" first="Jiangfan" last="Li">Jiangfan Li</name><name sortKey="Li, Junfeng" sort="Li, Junfeng" uniqKey="Li J" first="Junfeng" last="Li">Junfeng Li</name><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><name sortKey="Tai, Wanbo" sort="Tai, Wanbo" uniqKey="Tai W" first="Wanbo" last="Tai">Wanbo Tai</name><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000599 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000599 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6410414
|texte= Enhanced Ability of Oligomeric Nanobodies Targeting MERS Coronavirus Receptor-Binding Domain
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30791410" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |